In this review, we discuss four examples of neurite pruning across model organisms in order to explain the general features and cell biological mechanisms of pruning. But it is not only small synapses that can be removed through pruning, but also long stretches of axon or dendrite. For example, after a phase of rapid synapse formation during the first year after birth, the human brain experiences a steady decrease in synapse density during later development until a plateau is reached at the onset of adulthood ( Huttenlocher, 1990). Such regressive mechanisms are often collectively referred to as “pruning” (from a gardening expression that means “to weed out branches”) ( Schuldiner and Yaron, 2015). However, phases of neurite outgrowth are often also followed by phases of neurite removal during development. During development, neurites can grow long distances towards their respective target areas, and several mechanisms ensure that growing neurites find their proper synaptic targets with high precision. ![]() ![]() Information is passed on between neurons through synaptic connections. The long and often branched processes of neurons, axons and dendrites, are specialized compartments used to collect and propagate information, respectively. Rumpf where he is also a PhD student since 2015 and studies the mechanism of dendrite pruning. Rafael Krumkamp (*1987) studied Biology in Münster. Since 2013 PhD student at the University of Münster where she studies the mechanism of dendrite pruning. SvendeHerzmann (*1988) studied Biology in Münster. Klämbt on functional aspects of glial cells. Sandra Rode (*1987) studied Biology in Münster. Rumpf focuses on pruning mechanisms in Drosophila. ![]() Yuh Nung Jan, research group leader at the University of Münster, Germany since 2013. Postdoctoral work at the University of California San Francisco in the laboratory of Prof. Sebastian Rumpf (*1975) studied Biology in Heidelberg, PhD at the Max Planck Institute of Biochemistry (2006). Published by De Gruyter FebruMechanisms of Neurite Pruningĭr.
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